select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='50791' and ad.lang_id='9' and j.lang_id='9' and vi.lang_id='9' The Role of Circulating Myeloid-Related Protein Complex Calp | 50791
క్లినికల్ & ప్రయోగాత్మక కార్డియాలజీ

క్లినికల్ & ప్రయోగాత్మక కార్డియాలజీ
అందరికి ప్రవేశం

ISSN: 2155-9880

నైరూప్య

The Role of Circulating Myeloid-Related Protein Complex Calprotectin in Prediction of Heart Failure with Preserved Ejection Fraction

Alexander E Berezin

Both phenotypes of heart failure (HF) with preserved (HFpEF) and reduced (HFrEF) ejection fraction associate with various co-morbidities. The role of specific mediators in certain pathological conditions related to HFpEF and reduced HFrEF is not completely investigated. In this context, the discovery of novel biomarkers that might predict the development of HFpEF is attractive. The objective of the mini review: to investigate the potential role of calprotectin in identifying patients at higher risk of HFpEF phenotype development. Calprotectin (known as Myeloid- Related Protein complex 8/14, S100A8/A9) is calcium and zinc binding heterocomplex protein that was found in elevated level in several conditions associated with infections, inflammation, autoimmunity, allografts’ rejection, malignancy, obesity/metabolic disorders. In HF individuals calprotectin contributes to maintenance of contractile cardiac function and relaxing ability of ventricles, as well as it might reverse negative force-frequency interrelationship, improve sarcoplasmic reticulum Ca2+ uptake and protect against arrhythmia. There is a large spectrum of evidence regarding the role of exaggerated level of calprotectin in prediction adverse clinical outcomes in patients with HFpEF exhibits considerable clinical value and requires more investigations.

నిరాకరణ: ఈ సారాంశం కృత్రిమ మేధస్సు సాధనాలను ఉపయోగించి అనువదించబడింది మరియు ఇంకా సమీక్షించబడలేదు లేదా ధృవీకరించబడలేదు.
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