select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='90016' and ad.lang_id='9' and j.lang_id='9' and vi.lang_id='9' Rational Combinations of Active and Passive Immunotherapy Mo | 90016
జర్నల్ ఆఫ్ క్యాన్సర్ సైన్స్ అండ్ రీసెర్చ్

జర్నల్ ఆఫ్ క్యాన్సర్ సైన్స్ అండ్ రీసెర్చ్
అందరికి ప్రవేశం

ISSN: 2576-1447

నైరూప్య

Rational Combinations of Active and Passive Immunotherapy Mobilize Immune and Clinical Responses in Terminal Cancers

Deshmukh Dhanashri

Solid tumors encroach on the hosts immune microenvironment to favor its own proliferation. Strategies to enhance the specificity of the endogenous T cell population against tumors have been met with limited clinical success. We aimed to devise a 2-tier protocol coupling in vivo whole antigen priming with ex vivo cellular expansion to clinically evaluate survival in patients following re-infusion of primed, autologous T cells, determining treatment efficacy. Treatment commenced with the acquisition of whole tumor antigens from tumor cell lines corresponding with patients primary malignancy. Lysate mixture was inoculated intradermally while Peripheral Blood Mononuclear Cells (PBMCs) were periodically extracted via phlebotomy and expanded in culture ex vivo for re-infusion. Post treatment tumor- specific T cell response and cytotoxicity was confirmed via ELI Spot and Real-Time Cell Analyzing (RTCA) Assay. Because "cancer" refers to a class of diseases, it is unlikely that there will ever be a single "cure for cancer" any more than there will be a single treatment for all infectious diseases. Angiogenesis inhibitors were once thought to have potential as a "silver bullet" treatment applicable to many types of cancer, but this has not been the case in practice.

నిరాకరణ: ఈ సారాంశం కృత్రిమ మేధస్సు సాధనాలను ఉపయోగించి అనువదించబడింది మరియు ఇంకా సమీక్షించబడలేదు లేదా ధృవీకరించబడలేదు.
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