select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='95126' and ad.lang_id='9' and j.lang_id='9' and vi.lang_id='9' Prevention Strategies in Patients affected by Actinic Kerato | 95126
జర్నల్ ఆఫ్ క్లినికల్ & ఎక్స్పెరిమెంటల్ డెర్మటాలజీ రీసెర్చ్

జర్నల్ ఆఫ్ క్లినికల్ & ఎక్స్పెరిమెంటల్ డెర్మటాలజీ రీసెర్చ్
అందరికి ప్రవేశం

ISSN: 2155-9554

నైరూప్య

Prevention Strategies in Patients affected by Actinic Keratosis of the Head: A 12-Month, Prospective, Assessor-Blinded, Controlled Study with Lesion-Directed Treatment Associated with Medicalized Photoprotection

Arianna Lamberti, Alessandra Cartocci, Carolina Donelli, Giulio Cortonesi, Emanuele Trovato, Massimo Milani*, Pietro Rubegni, Elisa Cinotti

Objective: We assessed the efficacy of a 100+SPF sunscreen containing DNA-repairing enzymes (endonuclease, glycosylase, and photolyase) and a potent antioxidant extract (Polypodium Leucotomos Extract: PLE) (“Medicalized” Photoprotection: MP), in subjects with Actinic Keratosis (AK) treated with cryotherapy measuring the evolution of AKASI score and through a non-invasive analysis with Line-field Confocal-Optical Coherence Tomography (LC)- OCT.

Patients and Methods: A prospective, 12-month, assessor-blinded, controlled study enrolling patients with ≤ 5 actinic keratoses on the face and/or scalp suitable for cryotherapy was performed. After cryotherapy, 30 subjects were instructed to apply the MP twice daily for 12 consecutive months. Thirty subjects were selected as a control group. AKASI score was evaluated at baseline, after 3 and 12 months.

Results: MP was associated with a significant reduction (p<0.05) of AKASI score after 3 and 12 months. The score of the treatment group doesn't differ from the control group one at baseline, but it was significantly lower after 12 months. LC-OCT evaluation showed, at the end of treatment period in comparison with baseline that the thickness of the epithelium and the stratum corneum significantly decreased. A significant decrease of disarranged epithelial architecture, dyskeratotic keratinocytes, atypical nuclei and dilated vessels has been also observed. A significant increase (p=0.045) of the Outlined Dermo-Epidermal Junction (ODEJ), was observed.

Conclusion: PLE-based MP significantly improves AKASI score in subjects after cryotherapy treatment in comparison with controls. In addition, our study showed that morphological features identified by LC-OCT could be potentially useful for the follow-up of AK subjects.

నిరాకరణ: ఈ సారాంశం కృత్రిమ మేధస్సు సాధనాలను ఉపయోగించి అనువదించబడింది మరియు ఇంకా సమీక్షించబడలేదు లేదా ధృవీకరించబడలేదు.
Top
https://www.olimpbase.org/1937/