జర్నల్ ఆఫ్ సైకాలజీ & సైకోథెరపీ
అందరికి ప్రవేశం

నైరూప్య

వెన్నుపాము యొక్క సబ్-అక్యూట్ కంబైన్డ్ డిజెనరేషన్‌లో న్యూరోసైకియాట్రిక్ మానిఫెస్టేషన్స్ యొక్క క్లినికల్ మరియు MRI లక్షణాల సహసంబంధం: విటమిన్ B12 లోపంతో సంబంధం ఉన్న న్యూరోలాజికల్ సిండ్రోమ్

Ravinder Kumar, Kapil Vyas, Gagan Jaiswal, Abhishek Bhargava and Jyoti Kundu

Vitamin B12 or cynacobalamin is an important water soluble vitamin which plays a key role in erythropoiesis, proper nervous system functioning and for the metabolism of carbohydrate, fat and protein. Patients with cynacobalamin deficiency may present with haematological, gastro-intestinal, oral, dermatological, psychiatric and neurological disturbances. We present a case of sub-acute combined degeneration (SACD) of spinal cord in a fortynine year old female presenting with one month history of progressive symptoms of lower limb paraesthesia, sensory deficit, psychotic symptoms and postural instability. This case report is unusual as it elucidates the characteristic triad, i.e., haematological, psychiatric and neurological symptoms in sub-acute combined degeneration of spinal cord (SACD) associated with B12 deficiency, correlation of its clinical manifestations, electrophysiological signs, laboratory investigations ( especially biomarkers of B12 status) and spinal magnetic resonance (MR) imaging in establishing the diagnosis, treatment outcomes, and potential therapeutic relevance of vitamin B12 replacement therapy in symptoms remission.