ఫార్మాస్యూటికల్ అనలిటికల్ కెమిస్ట్రీ: ఓపెన్ యాక్సెస్
అందరికి ప్రవేశం
ISSN: 2471-2698
ISSN: 2471-2698
షెంగ్ వాంగ్, జియోటావో జు, యు జాంగ్, జియాక్సింగ్ హువాంగ్, యిఫీ వాంగ్, బిన్ జెంగ్, లి లియు మరియు క్విబింగ్ మెయి
The present study focuses on the anti-arthritic effect of Zushima cataplasms (ZC) in adjuvant arthritic (AA) rats. AA rats were treated with ZC from the 3rd day before immunization and continued until the 20th day after immunization. The severity of arthritis was evaluated by swelling, heat, nociceptive, histopathology and radiological changes. The levels of IL-1β, TNF-α in the serum were measured by ELISA. ZC showed no effect on alleviating swelling in primary inflammation, while ZC 0.75 g/kg dramatically reduced the swelling, and showed a significant increment of mechanical pain thresholds in secondary inflammation. The synovial hyperplasia and inflammatory cells infiltration were suppressed by ZC in secondary inflammation but not in primary inflammation. The radiographic studies further provided supportive evidence for histopathology analysis. Additionally, There was significant reduction in production of interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) in serum of AA rats treated with ZC.