జర్నల్ ఆఫ్ క్లినికల్ అండ్ సెల్యులార్ ఇమ్యునాలజీ
అందరికి ప్రవేశం

నైరూప్య

T cells in Immunobiology of Tumors and Immunotherapy

Vino T Cheriyan, Christella John Nelson and Prabha Balaram

Recent studies indicate that functional T-lymphocyte defects compromise anti-tumor responses in various cancers. It appears that tumors not only effectively bypassed the host immune system, but have also actively corrupted the host anti-tumor response via several distinct mechanisms. Cancer Immunotherapy has made significant strides in recent years, due to improved understanding of the underlying principles of tumor biology and immunobiology. This review attempts to identify strategic factors involved in anti-cancer immune impairment, understand the mechanisms underlying reported immunosuppression and highlight some of the most promising present day immunotherapy approaches progressing successfully in clinics.