జర్నల్ ఆఫ్ క్లినికల్ & ఎక్స్పెరిమెంటల్ డెర్మటాలజీ రీసెర్చ్
అందరికి ప్రవేశం

నైరూప్య

Regulatory Role Played by the mRNA Binding Protein Tristetraprolin in the Skin and its Involvement in Different Diseases

Roberta Lotti, , Tommaso Zanocco-Marani

The mRNA binding protein Tristetraprolin (TTP), encoded by the ZFP36 gene, plays a fundamental regulatory role in a wide variety of cellular processes by means of its widespread expression in different tissues, and of its ability to post transcriptionally regulate the stability, and therefore the expression, of multiple specific target mRNAs. Because of these features, TTP expression and activity are strictly regulated, and malfunctions of such mechanisms underlie different pathologies. Here we recapitulate the role of TTP in the skin, and its involvement in different conditions, with special reference to psoriasis and cancer.