select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='15678' and ad.lang_id='9' and j.lang_id='9' and vi.lang_id='9' Positive Correlation of RANK Expression on Human Monocytes w | 15678
జర్నల్ ఆఫ్ ఆస్టియోపోరోసిస్ అండ్ ఫిజికల్ యాక్టివిటీ

జర్నల్ ఆఫ్ ఆస్టియోపోరోసిస్ అండ్ ఫిజికల్ యాక్టివిటీ
అందరికి ప్రవేశం

ISSN: 2329-9509

నైరూప్య

Positive Correlation of RANK Expression on Human Monocytes with Age: RANK Expressed on Human Monocytes may play a Role in Senile Osteoporosis

Yuki Nanke, Tsuyoshi Kobashikawa, Toru Yago, Manabu Kawamoto, Hisashi Yamanaka, Shigeru Kotake

Background and aim: Receptor activator of NF-κB (RANK) is a member of the TNF receptor superfamily and a receptor for the RANK ligand (RANKL). We previously demonstrated that expression levels of RANK on monocytes are positively correlated with the level of osteoclastogenesis. In this study, we examined the expression of RANKhigh on CD14+ monocytes from patients with osteoarthritis patients (OA) and healthy volunteers (HV).

Methods: Peripheral blood samples were obtained from both OA and HV. To study the expression of RANKhigh on CD14+ monocytes, two-colour flow cytometry was performed. Using Spearman’s test, we studied the relation between the age and RANK.

Results: Expression levels of RANK on monocytes were positively correlated with the age (P=0.0027).

Conclusion: RANK expressed on human monocytes may play a crucial role in senile osteoporosis and may be a novel target for osteoporosis treatment.

నిరాకరణ: ఈ సారాంశం కృత్రిమ మేధస్సు సాధనాలను ఉపయోగించి అనువదించబడింది మరియు ఇంకా సమీక్షించబడలేదు లేదా ధృవీకరించబడలేదు.
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