క్లినికల్ & ప్రయోగాత్మక కార్డియాలజీ
అందరికి ప్రవేశం

నైరూప్య

Myocardial Protective Effect of Exogenous Creatine Phosphate in Children Undergoing Open Heart Surgery

Khan Mohammed Firoj, Hai bin Yu and Xian en Fa

Objective: To explore the protective role of exogenous Creatine Phosphate (PCr) in the postoperative cardiac muscle recovery in children undergoing open heart surgery.
Material and methods: 63 cases of congenital heart disease were randomly divided into 3 groups; A, B and C; 21 cases in each group. Myocardial perfusion fluids were made of the same amount of blood in the St, Thomas Hospital cardioplegic solution type 2 (STH 2). In B and C group, intraoperative myocardial perfusion solution added with exogenous CP. All the groups were postoperatively treated with general fluid therapy, while group C was given postoperative intravenous exogenous CP. Trends of myocardial enzyme at different time points were monitored.
Results: At the end of surgery (T2), enzyme levels in the plasma were significantly increased, no difference between the groups B and C but were significantly lower than that in group A (P<0.05); after surgery myocardial enzyme levels recovered fastest in Group C, slowest in A group, the differences between each group were significant (P<0.05).
Conclusions: Perioperative and postoperative exogenous PCr have myocardial protective effect and accelerate the repair of injured myocardium due to ischemia during open heart surgery in children.