జర్నల్ ఆఫ్ క్లినికల్ అండ్ సెల్యులార్ ఇమ్యునాలజీ
అందరికి ప్రవేశం

నైరూప్య

Influence of MNRI on the Immune Status of Children with Down Syndrome

Nelli Akhmatova and Elina Akhmatova

The clinical and immunological characteristics of 49 children with Down syndrome were studied. Thirty-four boys and 15 girls between the ages of zero and six years old were observed.
It was revealed that children in the Study Group with Down syndrome developed a greater number of disorders starting at the earliest stages of pregnancy and delivery, such as fetal malnutrition, congenital heart defects, and pathology of vision, than children in the control group (p<0.05). All of the children in the Study Group had allergic reactions and were frequently ill. There was a noticed decrease in the numbers of subpopulations of T-lymphocytes (СD45/CD3), CD3/CD4, CD3/CD8 and the absolute number of B-cells (CD45/CD19), and at IgG pool, indicating a certain deficiency in cell-mediated and humoral immune responses which provides a base for frequent diseases, including bacterial diseases. Also an increase in the prevalence of pre-activated cells (CD45/CD25) and NK cells (CD16/CD32/CD56), and a clear increase of IgE (1489.5 ± 467.9 и 59.67 ±11.8 IU/L in the control group, p<0.05) was noted, which explains the predisposition in children with Down syndrome to IgE-dependent humoral immune responses and allergic reactions. These specific indictors served as evidence that an evaluation of MNRI as a therapeutic program for improved immunity could be very beneficial. Tests done after two weeks of MNRI therapy showed normalizing of a significant number of abnormal indicators of T- and B- lymphocytes, NK-cells, immunoglobulin levels, and pro- and anti-inflammatory cytokines (IL-2, IL-4, IL-6, IL-10, IL-12, IL-17, IFN-γ, TNF-α).