రుమటాలజీ: ప్రస్తుత పరిశోధన
అందరికి ప్రవేశం

నైరూప్య

Infective Versus Libman Sacks Endocarditis In Systemic Lupus Erythematosus

Michael Thomas E Salvador and Sandra V Navarra

Background and objective: Libman Sacks endocarditis is a rare cardiac manifestation of Systemic Lupus Erythematosus (SLE). Cardiac valve vegetations may also be due to infective endocarditis especially in patients with risk factors. We report a case of stroke in an SLE patient with positive anti-phospholipid antibodies and echocardiography findings of mitral valve vegetations.

Case: A 33-year old female with stable SLE for 5 years on hydroxychloroquine and prednisone 5 mg/day presented with diplopia and intermittent fever of 2 weeks duration. She has had recurrent throat and gingival infections in the past year treated with antibiotics. Physical exam disclosed right lateral rectus and left medial rectus palsy, grade 3/6 holosystolic apical murmur, and livedo reticularis. Hemoglobin was 9.2 g/dl, and erythrocyte sedimentation rate (ESR) 130 mm/hr, leucocyte and platelet counts, serum complement, urinalysis, renal and liver functions were normal. Lupus anticoagulant and anti-cardiolipin antibody (IgG) were strongly positive. Cranial Magnetic Resonance Imaging (MRI) revealed an infarct at the pontomedullary area, and transesophageal echocardiogram visualized echodense structures on the mitral valve consistent with vegetations. Blood cultures were negative for microorganisms. She was treated with high-dose steroid tapered to prednisone 20 mg/day, tinzaparin later shifted to warfarin and an antibiotic regimen consisting of penicillin and gentamycin administered for 2 weeks; hydroxychloroquine was continued. She was afebrile throughout hospitalization, with gradual resolution of the neurologic manifestations. A repeat cranial MRI 3 weeks later was normal.

Conclusion: This case highlights the challenges in clinically differentiating infective endocarditis from Libman Sacks endocarditis in a patient with risk factors for both conditions. She received empiric treatment for both with favourable outcome.

Funding: Lupus-Inspired Advocacy (LUISA) Project of Rheumatology Educational Trust Fund Inc. (RETFI).