select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='34178' and ad.lang_id='9' and j.lang_id='9' and vi.lang_id='9' Induced Pluripotent Stem Cells for the Treatment of Hemophil | 34178
జర్నల్ ఆఫ్ సెల్ సైన్స్ & థెరపీ

జర్నల్ ఆఫ్ సెల్ సైన్స్ & థెరపీ
అందరికి ప్రవేశం

ISSN: 2157-7013

నైరూప్య

Induced Pluripotent Stem Cells for the Treatment of Hemophilia A

Bilgimol C Joseph and Manjunath S Rao

Factor VIII, one of the most complex proteins known, plays a major role in blood coagulation pathway. Defects in factor VIII protein result in hemophilia A, a severe bleeding disorder. Plasma derived factor VIII or recombinant factor VIII has been used extensively for treating hemophilia A patients. Number of attempts at gene therapy for hemophilia A has failed for various unknown/not much studied reasons including immune rejection. Here, the progress that has been made in establishing iPSC-based disease models and the potentials of iPSC technology for personalized medicine and cell therapy for hemophilia A are reviewed. The challenges of iPSC technology are also briefly discussed.

నిరాకరణ: ఈ సారాంశం కృత్రిమ మేధస్సు సాధనాలను ఉపయోగించి అనువదించబడింది మరియు ఇంకా సమీక్షించబడలేదు లేదా ధృవీకరించబడలేదు.
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