డ్రగ్ డిజైనింగ్: ఓపెన్ యాక్సెస్
అందరికి ప్రవేశం

నైరూప్య

Formulation and Evaluation of Proniosomes of Felodipine

Mahesh Boddu, Vijendar Choppari, Vamshi Krishna Rapalli and Manikanta Badam

Novel drug delivery systems have emerged embracing various routes of administration, oral drug delivery is the most common and preferred method of drug administration. A lipid based drug delivery has become an emerging strategy for improved oral delivery of poorly soluble drugs. Drug encapsulation in the vesicles is one such system which helps to prolong drug duration in systemic circulation and decreases the toxicity by selective uptake. Based on this technique, a number of vesicular drug delivery systems such as liposomes, niosomes and provesicular systems like proliposomes and proniosomes have been developed. The aim of the present investigation was to develop felodipine proniosomes to enhance the solubility. Felodipine loaded proniosomes were prepared by varying ratios of span 60 and cholesterol by solvent evaporation method. Proniosomes were characterized for vesicle size, micromeritics, entrapment efficiency and dissolution behavior. Solid state behavior was evaluated by Differential scanning calorimetry (DSC), Scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) studies. The formulated proniosomes showed improved dissolution characteristics which were assessed from dissolution efficiency, mean dissolution rate data. The transformation of crystalline form of the drug to amorphous and/or molecular state was represented by solid state characterization. FTIR studies showed that absence of interaction between drug and other formulation excipients.