యాంటీవైరల్స్ & యాంటీరెట్రోవైరల్స్ జర్నల్
అందరికి ప్రవేశం

నైరూప్య

Development of 2′-Deoxy-4′-C-Ethynyl-2-Fluoroadenosine (EFdA) which has Supremely High Anti-HIV Activity and Low Toxicity and Prevents the Emergence of Resistant HIV Mutants, and Discovery of Different Substrate Selectivity between Viral and Human Nucleic Acid Polymerases

Hiroshi Ohrui

The development of 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (EFdA) which has supremely high anti-HIV activity and low toxicity and prevents the emergence of resistant HIV mutants was achieved by the studies based on the author’s working hypotheses, and a very important discovery that the substrate selectivity of viral RNA-dependent nucleic acid polymerases is different from that of human DNA-dependent nucleic acid polymerases was made by these studies.