అనస్థీషియా & క్లినికల్ రీసెర్చ్
అందరికి ప్రవేశం

నైరూప్య

Comparison of 3 Different Dexmedetomidine Doses and Their Effect on the Duration of Spinal Anesthesia

Bassant Mohamed Abd Elhamid and Hassan Mohamed Ali

Background and aim: Dexmedetomidine has been tested in many studies as an adjuvant to prolong spinal anesthesia duration with no clear recommendation regarding the optimum dose. This study test very minimal dose of Dexmedetomidine 1.5 μg vs. 3 μg and 5 μg to find out the least effective dose.

Methods: 94 patients were recruited and randomly divided into 4 groups C, D1.5, D3 and D5 received saline, 1.5 μg, 3 μg and 5 μg Dexmedetomidine respectively in combination with the levobupivacaine through intrathecal route. Duration of the spinal anesthesia, sedation score and complications were noticed and recorded in all the groups.

Results: there was an increase in sensory block duration with the increase in dose (dose-related prolongation) as it was 215.9 ± 82.4 min in group C, 219.7 ± 52 min in group D1.5, 301.3 ± 42.3 min in group D3 and 365.4 ± 96.4 min in group D5. However, there was neither statistical nor clinical significance between the control group and group D1.5 (p-value was 0.23). On the other hand, there was neither statistical nor clinical significance regarding the sedation level or the complications.

Conclusions: Dexmedetomidine has an effect on the duration of the spinal anesthesia all through its doses. However, there is no clinical significance with dose 1.5 μg