ఎమర్జెన్సీ మెడిసిన్: ఓపెన్ యాక్సెస్
అందరికి ప్రవేశం

నైరూప్య

Assesment of the Vasoactive Intestinal Polypeptide (VIP) in Morphologically Normal Appendices Removed from Patients with Clinical Diagnosis of Acute Appendicitis

Thiago Vinicius Villar Barroso, Paulo Guilherme Oliveira Sales and Andy Petroianu

Background: Correct diagnosis of acute appendicitis is one of the most challenging issues in surgery. About 15% to 40% of all appendectomies result in the removal of morphologically normal appendices.
Objective: To assess values of the vasoactive intestinal polypeptide (VIP) in the presence of normal and inflamed appendices removed due to clinical diagnosis of acute appendicitis.
Patients and Methods: The appendices removed from 76 patients were divided into three groups as follows: group 1: 50 morphologically normal appendices that were removed due to clinical diagnosis of acute appendicitis; group 2: 10 normal appendices prophylactically removed during other surgical procedures; group 3: 16 inflamed appendices with a morphological aspect of acute appendicitis. Histological and immunohistochemical studies defined the characteristics of each appendix of all groups.
Results: Groups 1 and 2 did not differ between themselves, but group 3 showed a greater degree of color reaction for VIP than groups 1 and 2.
Conclusion: Morphologically normal appendices removed due to a clinical diagnosis of acute appendicitis do not present the immunohistochemical changes for the VIP that is found in inflamed appendices.