select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='94048' and ad.lang_id='9' and j.lang_id='9' and vi.lang_id='9' All Roads Lead to Rome: Complexity of Signalling Pathways in | 94048
జర్నల్ ఆఫ్ సెల్ సిగ్నలింగ్

జర్నల్ ఆఫ్ సెల్ సిగ్నలింగ్
అందరికి ప్రవేశం

ISSN: 2576-1471

నైరూప్య

All Roads Lead to Rome: Complexity of Signalling Pathways in Cancer

Trupti Togar, Usha Patel, Srikanthi Ramachandrula, Narendra Chirmule

The complexity of signalling pathways in cancers is often responsible for the failure of therapy or the emergence of therapy resistance. Cancer can no longer be viewed as an outcome of one driver gene, as multiple factors are involved. Activation of oncogenic signalling pathways can provide answers regarding disease pathogenesis. The cross-talk between signalling pathways, network re-wiring, feedback mechanisms, and gene redundancy functions are major contributors to therapy resistance which need to be considered to predict effective therapy. In this article, we provide a comprehensive overview of the intricacies of 9 signalling pathways commonly found to be deregulated in several cancer types.

నిరాకరణ: ఈ సారాంశం కృత్రిమ మేధస్సు సాధనాలను ఉపయోగించి అనువదించబడింది మరియు ఇంకా సమీక్షించబడలేదు లేదా ధృవీకరించబడలేదు.
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