Murat Turkyilmaz*, Murat Donmez, Murat Ates
In this work, firstly, water soluble carbene compounds were firstly synthesized in literature. Secondly, new Nheterocyclic metal complexes were obtained from silver (I) metal and functional carbene compounds. The aims of these syntheses are to use them in pharmacology as cancer drugs and the catalysis of organic reactions.
The main skeleton of the 5,6-dimethylbenzimidazole molecule combined with functional bromide groups to form heterocyclic carbenes with symmetrical properties. The NHC precursor compounds reacted with Ag2O to form Ag (I)-NHC complexes. Ag (I)-NHC complexes were characterized by different techniques, such as melting point analysis, conductivity, 1H and 13C-NMR, LC-MS, FTIR, TGA, XRD and UV-vis spectrophotometry. The antimicrobial and antibacterial activities of Ag (I)-NHC complexes were investigated against gram negative, gram positive bacteria, and fungi using the disc diffusion method. All tested complexes showed antimicrobial activity with different specifications. MIC value 0.02 μg/ml.