అనస్థీషియా & క్లినికల్ రీసెర్చ్
అందరికి ప్రవేశం

నైరూప్య

Predicting Failure of Non-invasive Ventilation in a Mixed Population

Anders Bastiansen

Objective: Non-invasive ventilation (NIV) is widely used as part of the treatment of acute respiratory failure but it is not always successful. The purpose of this study is to determine if NIV failure can be predicted on the basis of information available at the initial point of contact with the patient.

Methods: This is a retrospective study of patients admitted to a six bed non-specialized ICU at Køge University Hospital (Denmark) in the years 2011-2012. Patients were assigned to one of two groups covering successful NIV treatment and NIV failure.

Results: 89 patients were included and the two groups were compared on variables available at the initial point of contact with the patient. Patients in whom NIV treatment failed had higher levels of C-reactive protein (p=0.04). Multivariate analysis showed an odds ratio of 1.13 (95% CI: 1.02-1.25) for NIV failure associated with increased respiratory rate. NIV was less likely to fail in patients with known Chronic Obstructive Pulmonary Disease (p=0.05). The mean duration of NIV before intubation in case of NIV failure was 14.1 hours (SD: 15.0) and was not associated with neither the ICU nor the in-hospital mortality.

Conclusion: In the present study NIV failure was associated with higher levels of C-reactive protein and increased respiratory rates carried an odds ratio of 1.13 (95% CI: 1.02-1.25) for NIV failure.