జర్నల్ ఆఫ్ క్లినికల్ ట్రయల్స్
అందరికి ప్రవేశం
ISSN: 2167-0870
ISSN: 2167-0870
Qiang Yi, Yu Ran, Cong Li*
Objective: Epithelial Ovarian Cancer (EOC) in early stage is difficult to diagnose. Serum indicators for stage I-II of epithelial ovarian cancer which confined to pelvic cavity were found through retrospective analysis, possible early detection methods might be found.
Methods: 165 patients were diagnosed as epithelial ovarian cancer at stage I-II from January 1st, 2015 to December 31st, 2019. Data was collected including age, pathological type, serum D-dimer (D-D), Neutrophil to Lymphocyte ratio (N/L), the platelet to Lymphocyte ratio (P/L), Cancer Antigen 125 (CA125), Human Epididymis Protein 4 (HE4) and diameter of the ovarian mass by ultrasound.
Results: D-D, CA125, HE4, ROMA, diameter, pathological type and age were significantly different in the different stage, age showed independent effect after logistical regression (P<0.05). D-D, CA125, HE4, ROMA, diameter, age and stage were significantly different in the different pathological type, and diameter showed significant independent influence on different pathological type after binary logistic regression (P<0.05).
Conclusion: CA125, HE4, ROMA, diameter of tumor, D-dimer and age were found significantly different between stage I and stage II, with age shows good effect on the diagnosis for stage II and diameter of tumor shows diagnostic value for non-serous ovarian cancer. Combined diagnosis may improve the diagnosis rate of early ovarian cancer.