Bilembi Mbote Olivier*, Boxi Feng, Yubo Zhou, Mingyu Zhang, Yindi Wang, Zhen Lv, Sansan Li, Yahui Xie, Xingmin Wei, Jianjun Wu, Yuqin Liu
Aim: The study aims to examine the correlation between alcohol consumption and the risk of gastric cancer in the Wuwei population with different levels of H. pylori infection.
Methods: The study included 3123 participants aged 40-70 years who had resided in Wuwei city for at least 5 years. Participants completed questionnaires on personal information, diet, alcohol consumption, family and medical history and H. pylori detection. All participants underwent 13C-Urea Breath Test (13C-UBT) for H. pylori infection and upper gastrointestinal endoscopy and pathology were performed. Testing was conducted before diagnosis to avoid recall bias.
Results: Alcohol increases the risk of gastric cancer, but it decreases the risk in those who are infected. Those aged 50-70 without H. pylori who consume alcohol and smokers who quit with H. pylori infection have a higher risk of gastric cancer.
Conclusion: Alcohol consumption represents a significant risk factor for the development of gastric cancer. This risk is particularly pronounced with advancing age and following the eradication of H. pylori.